Vasopressin

Vasopressin (also known as antidiuretic hormone or arginine vasopressin) is a naturally occuring hormone produced in the hypothalamus that has vasoconstrictive and antidiuretic effects. During states of shock, levels of vasopressin are low and exogenously administered vasopressin exerts profound vasoconstrictive effects.

20 IU of vasopressin (or matching placebo) will be administered after each dose of adrenaline for a maximum of 80 IE.

Methylprednisolone

Methylprednisolone is a synthetic glucocorticoid which is a class of corticosteroids that is part of the larger group of steroid hormones. Glucocorticoids are produced in the adrenal cortex and exerts a wide range of functions in the body including regulation of metabolism, inflammation, and cell proliferation. During situations with stress, glucocorticoids are secreted as a defense mechanism exerting widespread physiological functions.

40 mg of methylprednisolone (or matching placebo) will be administered after the first dose of adrenaline.